Chronic Pain Releases Parabrachial Activity from Central Amygdala Inhibition
نویسندگان
چکیده
منابع مشابه
Synaptic and network consequences of monosynaptic nociceptive inputs of parabrachial nucleus origin in the central amygdala
A large majority of neurons in the superficial layer of the dorsal horn projects to the lateral parabrachial nucleus (LPB). LPB neurons then project to the capsular part of the central amygdala (CeA; CeC), a key structure underlying the nociception-emotion link. LPB-CeC synaptic transmission is enhanced in various pain models by using electrical stimulation of putative fibers of LPB origin in b...
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Previous studies have shown that benzodiazepines, such as chlordiazepoxide (CDP), increase palatability through GABAA agonistic effects within the parabrachial nucleus (PBN). The PBN is a primary relay point in the gustatory pathway that receives input from corticofugal projections including the central amygdala (CeA). The purpose of this study was to determine the effects of selectively inacti...
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The central amygdala (Ce), particularly its medial sector (CeM), is the main output station of the amygdala for conditioned fear responses. However, there is uncertainty regarding the nature of CeM control over conditioned fear. The present study aimed to clarify this question using unit recordings in rats. Fear conditioning caused most CeM neurons to increase their conditioned stimulus (CS) re...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2020
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.1013-20.2020